Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes—Link to analyte properties

In the present fundamental study, selectivity and efficiency of electromembrane extraction 50 polar basic substances (?6.7 < log P +1.0) was systematically studied for ten different supported liquid membranes. For each model substance, 23 molecular descriptors were collected these investigated as potential parameters understanding by means partial least squares regression. Overall, a highly aromatic deep eutectic solvent composed coumarin thymol with addition 2% ionic carrier (di(2-ethylhexyl) phosphate) provided highest an average yield 69% from pure water samples, 55% plasma, 62% urine. With this system, ionic, cation-?, ?-? interactions between membrane analytes dominant. Supported membranes without aromaticity, however, operated primarily based on hydrogen-bonding interactions. This is first time relationship analyte properties, composition, has been bases in extraction. new knowledge represents step toward enabling future development optimization systems rational design, rather than trial-and-error approaches.